Since its emergence in late 2019, COVID-19 has sparked global catastrophe, taking the lives of millions around the world. This pandemic has deeply challenged the global community across sectors, including health and economics. Constantly evolving information led to millions of publications related to the disease in less than two years, a ground-breaking magnitude in the world of academic. This book “Critical Care and COVID-19” summarizes what we know about COVID-19 as it pertains to epidemiology, pathology, therapeutics, and effects on different organ systems. It also dives into the mental health challenges as a result of COVID-19, the nursing and respiratory therapist journey, and lessons learned from the frontline. This 25-chapter book covers the COVID-19 spectrum and benefits clinicians, nurses, respiratory therapists, pharmacists, and regulators.