This publication summarizes the latest scientific data on etiopathogenesis, genetics, clinic, diagnosis and therapy of chronic B-cell lymphoproliferative diseases. The results of studies of diseases of this group with comparison of the effectiveness of different therapy schemes are presented. The role of genetic factors in the occurrence of chronic lymphoproliferative diseases is highlighted, the most important molecular markers are emphasized. For hematologists, therapists, senior medical students, interns, residents, postgraduate students.